Pancreatic cancer nature reviews. In this Review, the authors explore the improvements in pancreatic cancer treatment obtained in the past few years Dec 1, 2002 · Advances in pathological classification and cancer genetics have improved our descriptive understanding of this disease; however, important aspects of pancreatic cancer biology remain poorly Oct 1, 2024 · New research published in Nature Genetics shows how neoadjuvant chemotherapy and radiotherapy affect the tumour microenvironment (TME) in pancreatic ductal adenocarcinoma using single-cell spatial Jun 4, 2021 · Vast developments are being made within the field of pancreatic cancer genomics. found that C-X-C chemokine receptor type 2 (CXCR2) expression in neutrophils and myeloid-derived suppressor cells (MDSCs) at tumour borders correlates with poor prognosis in Sep 3, 2010 · Review Article Published: 03 September 2010 KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma John P. There are few therapeutic options and many promising drugs have failed in patients, which makes better models to May 1, 2006 · Pancreatic cancer has an extremely poor natural course, and early diagnosis is difficult owing to its location and the lack of early markers for the disease. Furthermore, the Mar 19, 2019 · Published: 19 March 2019 PANCREATIC CANCER Autophagy inhibitor combination strategies for pancreatic cancer Iain Dickson Nature Reviews Gastroenterology & Hepatology 16, 262–263 (2019) Cite this Mar 2, 2016 · An integrated analysis of 456 pancreatic ductal adenocarcinomas has identified molecular subtypes of pancreatic cancer. This Review summarizes the latest findings of microbiota association studies of tumours of the pancreas and outlines the mechanisms Apr 21, 2016 · In 2015, an estimated 367,000 new cases of pancreatic cancer were diagnosed worldwide; this disease is aggressive and patients face a dismal overall prognosis. Hruban Nature Reviews Gastroenterology & Hepatology 12, 431 Featured Currently there are no Pancreatic cancer articles found within Nature Reviews Neuroscience Try browsing wider or narrow subjects, or alternatively you can: Browse Pancreatic cancer across Jun 1, 2020 · Obesity is a known risk factor for pancreatic cancer. In this Review, we discuss advances and practice-changing trials for PDAC. Crist, Sara S. In this review Pancreatic cancer is the fourth leading cause of cancer death in the US, with over 35,000 deaths reported in 2009. Azad Nature Reviews Gastroenterology & Hepatology Aug 12, 2024 · From 26–29 June 2024, Nature Reviews Gastroenterology & Hepatology attended the 56th meeting of the European Pancreatic Club (EPC) in Santiago de Compostela, Spain. It secretes pancreatic juices into the small intestine to digest food, and secretes insulin into the Jun 2, 2023 · Pancreatic ductal adenocarcinoma (PDAC) has very poor survival rates and is largely insensitive to immune checkpoint blockade therapy. In this Review Raimondi and colleagues discuss Sep 10, 2024 · Using pancreatic cancer xenograft models, the authors found that inhibiting MNK using eFT508 in mice fed a ketogenic diet limited pancreatic cancer growth. et al. This Review outlines the current knowledge of established pancreatic cancer risk factors, including lifestyle and inherited risk May 6, 2025 · Perspective Published: 06 May 2025 Improving outcomes of patients with pancreatic cancer Stephan B. Nov 30, 2023 · In this Review, Besselink and colleagues discuss preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable pancreatic cancer and locally advanced Jul 9, 2021 · Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer and pancreatic ductal Sep 8, 2025 · Nature Reviews Gastroenterology & Hepatology - Vaccine for pancreatic and colorectal cancer: phase I AMPLIFY-201 trial Affiliations 1 Sidney Kimmel Comprehensive Cancer Center, The Skip Viragh Pancreatic Cancer Center for Clinical Research and Care, and The Bloomberg-Kimmel Institute for Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, MD, USA. Nov 23, 2010 · Pancreatic cancer is a highly aggressive malignancy, which is partly attributable to drug resistance. Article CAS PubMed PubMed Central Google Scholar Jun 1, 2020 · Most patients who undergo curative intent surgery for pancreatic cancer will still die of recurrent disease. Canto & Ralph H. 1 In 1997, gemcitabine became the standard of care for advanced disease and since May 7, 2013 · As pancreatic cancer is fundamentally a genetic disease, the authors of this Review emphasize the complex mutational heterogeneity of pancreatic ductal adenocarcinomas and the importance of moving May 4, 2010 · This Review discusses the current state of the field of pancreatic cancer chemo-prevention and highlights the challenges ahead. Morris IV, Sam C. The study was based on data from 6 million people in Denmark and 3 Jun 14, 2024 · News & Views Published: 14 June 2024 Pancreatic cancer Unlocking the promise of RAS inhibition in pancreatic cancer Saurav D. In this Review, Besselink and colleagues discuss preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable pancreatic cancer and locally advanced Nov 22, 2024 · Research Highlight Published: 22 November 2024 Pancreatic cancer The ins and outs of tumour resistance Michael Attwaters Nature Reviews Gastroenterology & Hepatology 22, 7 (2025) Cite this article This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies for using a molecular taxonomy to guide therapeutic development and ultimately routine therapy with the overall goal of improving outcomes for this disease. Currently, prevention or early diagnosis Jul 1, 2008 · An increase in coagulation in patients with pancreatic carcinoma has long been documented. May 9, 2023 · Journal Club Published: 09 May 2023 Preprint watch Pancreatitis points to key role of dendritic cells in pancreatic cancer Lucas Baldran-Groves & Jeroen Melief Nature Reviews Immunology 23, 345 Jul 3, 2012 · Review Article Published: 03 July 2012 Applying next-generation sequencing to pancreatic cancer treatment Elaine R. Jaffee Nature Reviews Cancer 5, 459–467 (2005) Cite this Mar 19, 2021 · This Review discusses metabolism in pancreatic cancer, including insights into mechanisms and processes as well as the potential therapeutic applications. Mar 17, 2023 · Advances in surgical technique and chemotherapy regimens have improved the survival outcomes of patients with pancreatic cancer, although these remain dismal relative to most other solid tumours Abstract Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most lethal human malignancies. May 8, 2025 · Pancreas articles from across Nature Portfolio The pancreas is a large gland in the abdomen. Apr 17, 2012 · This Review presents a comprehensive summary of current knowledge of miRNA-mediated metabolic regulation in cancer, with a particular focus on pancreatic cancer. 0% per year, and it is projected to become the Apr 19, 2018 · The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. have identified a rare subpopulation of pancreatic acinar cells in the exocrine compartment that renews the pancreas by fuelling clonal expansion. May 26, 2021 · Pancreatic cancer is a deadly disease with poor outcomes and is predicted to be the second leading cause of cancer death in some regions by 2030. Sep 18, 2024 · Spot-based spatial transcriptomic analysis of paired primary and metastatic pancreatic cancers identifies cellular, metabolic and fibrotic changes in ecotypes associated with progression Mar 17, 2022 · The cell of origin of pancreatic cancer has long been controversial. Mar 7, 2011 · This Review discusses the salient clinicopathological and molecular features of the clinically most important precursor lesions of invasive pancreatic cancer. Moreover, discerning the molecular characteristics of Apr 21, 2016 · Pancreatic stellate cells are stromal Nature cells Reviews that can | Disease interact Primers with cancer cells, with other cells in the desmoplastic reaction (including immune cells, endothelial Mar 7, 2025 · A previous phase I trial reported that a personalized RNA neoantigen vaccine was safe and stimulated anti-tumour CD8 + T cells in patients with pancreatic cancer that correlated with delayed This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Cancer Discov. Yet, recent studies suggest PDAC harbours more neoantigens Jun 9, 2009 · Pancreatic cancer is lethal and notoriously difficult to treat, therefore, there is an urgent need to develop new therapeutic and diagnostic modalities. Currently, prevention or early diagnosis at a curable stage is exceedingly difficult; patients rarely exhibit symptoms and tumours do not display … Apr 21, 2016 · This PrimeView highlights the interplay between genetic mutations, signalling pathway aberrations, microenvironmental disturbances and metabolic reprogramming that underlie the development of May 1, 2018 · For decades, the 5-year survival for pancreatic cancer remained largely static. Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. In this Review, we present what is known about the pathophysiology of increased coagulation in cancer and Sep 30, 2019 · In September 2019, Nature Reviews Gastroenterology & Hepatology visited Boston, USA, to attend a special conference from the American Association for Cancer Research on Pancreatic Cancer: Advances Mar 29, 2022 · Hosein et al. Familial pancreatic cancer registries are important for investigating the genetic Jan 7, 2025 · Pancreatic cancer is a highly lethal disease with a low survival rate, primarily due to late diagnosis and to the formation of a dense fibrous environment around cancer cells that reduces This Review outlines the state-of-the-art therapies for patients with pancreatic cancer, as well as the novel treatment strategies that are the focus of drug-development efforts. Biankin Nature Reviews Clinical Oncology 22 Apr 25, 2025 · This Review article outlines the controversies surrounding the treatment options for patients with advanced-stage pancreatic cancer, from surgery through to chemotherapy, radiotherapy, targeted Oct 5, 2023 · The incidence of pancreatic ductal adenocarcinoma (PDAC) is rising. This Review focuses on precancerous lesions of the pancreas, describing their pathological and molecular Oct 14, 2014 · Plasma levels of branched-chain amino acids (BCAA) are increased in early pancreatic ductal adenocarcinoma (PDAC), according to a study published in Nature Medicine. We briefly review therapeutic failures Nov 17, 2021 · This Review outlines our current understanding of the evolution and heterogeneity of pancreatic ductal adenocarcinoma (PDAC), which has advanced owing to the study of preclinical models and May 12, 2020 · Important research efforts are being made to develop therapeutic strategies targeting the tumour microenvironment in pancreatic adenocarcinoma. Nature 618, 144–150 (2023). Pancreatic Jan 31, 2020 · This Review discusses the role of oncogenic KRAS in the biology, diagnosis, prognosis and treatment of pancreatic cancer. investigated the high levels of autophagy in pancreatic ductal adenocarcinoma (PDAC). 8, 403–416 (2018) Article PubMed CAS Google Scholar Download references Jan 9, 2025 · Sears and colleagues found that ongoing replication stress pathways and T cell clonal responses differentiate liver and lung recurrence and are associated with different clinical outcomes in the Identification of the genetic changes that underlie pancreatic cancer not only provides insight into the aetiology of this cancer but also provides an opportunity to guide early detection strategies. Nov 22, 2024 · Pancreatic cancer is a leading cause of cancer death worldwide. May 3, 2022 · Metagenomics of faecal and salivary samples from Japanese patients with treatment-naive pancreatic ductal carcinoma (PDAC) (n = 47) and individuals with non-PDAC as controls (n = 235) revealed 30 Apr 23, 2025 · Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the Jan 16, 2025 · Research on pancreatic cancer has transformed with the advent of organoid technology, providing a better platform that closely mimics cancer biology in vivo. This Review discusses the wide-ranging and most current research with the goal of integrating this information into The Australian Pancreatic Cancer Genome Initiative identified novel mutated genes involved in DNA damage repair and chromatin modi-fications in 142 patients with early-stage PDAC27. Historically, histological similarity suggested ductal cells, as reflected in the term ‘ductal adenocarcinoma’, as the cell Jun 30, 2015 · News & Views Published: 30 June 2015 Diagnosis A step closer to screening for curable pancreatic cancer? Marcia I. In this Review, Hu and O’Reilly summarize the latest advances and clinical trials for the treatment of PDAC, including 2 days ago · The gut microbiome has been associated with pancreatic cancer. Cancer of the exocrine component of the pancreas Jun 29, 2021 · Pancreatic cancer is a notoriously lethal condition characterised by aggressive malignancy and dismal outcomes. Dec 7, 2023 · In a new study published in Nature, researchers have investigated the role of tumour-associated macrophages (TAMs) in pancreatic cancer. However, translational advances are showing us that hope is on the horizon. Hingorani & Andrew V. Sep 7, 2021 · Abstract Importance: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer, with approximately 60 430 new diagnoses expected in 2021 in the US. Apr 21, 2016 · Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall prognosis that has remained virtually unchanged for many decades. Haldar & Nilofer S. It has previously been shown that pancreatic ductal Mar 26, 2019 · Channing Der and Kirsten Bryant discuss recent work leading towards therapeutic targeting of autophagy in pancreatic cancer. This Viewpoint discusses whether it is Oct 26, 2021 · This Review outlines our current understanding of the evolution and heterogeneity of pancreatic ductal adenocarcinoma (PDAC), which has advanced owing to the study of preclinical models and Jun 5, 2023 · Research Highlight Published: 05 June 2023 Tumour immunotherapy Combining EZH2 inhibition with senescence induction helps immune cells fight pancreatic cancer Yvonne Bordon Nature Reviews Jul 14, 2015 · Promising advances are currently being made in the search for reliable biomarkers that can facilitate the early detection of pancreatic cancer. A new study shows that pancreatic tumours that pass through the genetic bottlenecks of Jun 7, 2021 · Pancreatic cancer is typically diagnosed at a late stage and early detection is a priority. This Review outlines the current knowledge of established pancreatic cancer risk factors, including lifestyle and inherited risk Sep 23, 2011 · Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer that is involved in the generation of pain, and correlates with poor prognosis in most studies. Hook & Scott E Aug 18, 2009 · Here we review the current knowledge on pancreatic cancer stem cells and the implementation of cancer stem cell markers as prognostic or predictive biomarkers. discuss the current therapeutic landscape in pancreatic cancer as well as the translational and clinical implications and the challenges to overcome. Wainberg & Eileen M. Zeh, Rui Kang, Guido Kroemer & Daolin Tang Nature Reviews Gastroenterology Aug 17, 2016 · Review Article Published: 17 August 2016 Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer Pavan P. Jul 25, 2018 · Pancreatic cancer is a disease with high tumour heterogeneity and dismal prognosis. Dec 6, 2012 · Pancreatic cancer is a leading cause of cancer death, and it has the poorest prognosis of any major tumour type. The incidence of PDAC is increasing by 0. Adiseshaiah, Rachael M. Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche. O’Reilly Nature Reviews Clinical Nov 29, 2022 · Review Article Published: 29 November 2022 Epithelial and stromal co-evolution and complicity in pancreatic cancer Sunil R. Mardis Nature Reviews Gastroenterology & Hepatology 9, 477–486 (2012) Cite Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer, with approximately 60 430 new diagnoses expected in 2021 in the US. Article CAS PubMed PubMed Central Google Scholar Jan 15, 2024 · In a recent Developmental Cell paper, Falvo et al. This Focus Aug 5, 2024 · A recent study in Nature Medicine describes a multi-parametric profile of a pre-metastatic signature using liver biopsy samples to predict metastatic outcomes in early-stage pancreatic cancer (PaC Feb 4, 2019 · This Review summarizes current knowledge concerning the molecular subtyping of pancreatic cancer and explores future strategies using molecular taxonomy to guide Jul 9, 2024 · Pancreatic cancer is one of the deadliest forms of cancer with limited treatment options and a critical need for prognostic biomarkers. A study now leverages real-world data to identify distinct molecular and immune Jul 29, 2025 · In this Review, the authors provide an overview of the various neoadjuvant therapy approaches for patients with pancreatic cancer, including discussions of several promising future research directions Jul 22, 2016 · This Review brings many aspects of pancreatic ductal adenocarcinoma research into a single concept rooted in Darwinian evolution, with the goal of identifying novel insights and opportunities for Jan 7, 2021 · Year in Review Published: 07 January 2021 PANCREATIC CANCER IN 2020 The war against pancreatic cancer in 2020 — advances on all fronts Tejeshwar Jain & Vikas Dudeja Nature Reviews Oct 27, 2021 · Neuhöfer et al. Much is known regarding the biology and pathophysiology of PDAC, but translating this knowledge to the clinic to improve patient outcomes has been challenging. Read the latest Research articles in Pancreatic cancer from Nature Reviews Endocrinology Survival in patients with advanced pancreatic cancer is particularly poor, and improvements in diagnosis and treatment are urgently needed. Iacobuzio-Donahue Nature Reviews Gastroenterology & Hepatology 20, 75–76 (2023) Cite this article Apr 19, 2018 · In this Review, the authors explore the improvements in pancreatic cancer treatment obtained in the past few years and discuss key questions related to the future development of new therapies. The authors of this Review describe the apparent Mar 31, 2015 · Herein, we review the state-of-the-art of pancreatic cancer treatment, and the upcoming novel therapeutics that hold promise in this disease are also discussed. Current research is focused on elucidating the role of the tumour microenvironment and the Jul 22, 2019 · An urgent clinical need exists to improve the survival of patients with pancreatic cancer through biomarker-driven therapeutic strategies. 6 Jul 16, 2013 · This Review summarizes emerging data on the role of mucins in the development and progression of pancreatic cancer and its microenvironment. In this Review the authors discuss neural plasticity in pancreatic diseases such as pancreatitis and SUMMARY Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. 6 indicate that the cancer-associated fibroblast (CAF) population in the tumour microenvironment of pancreatic ductal adenocarcinoma (PDAC) is even more complex than Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most lethal human malignancies. A. Identification of new biomarkers and targets in Mar 27, 2023 · Research Highlight Published: 27 March 2023 Pancreatic cancer Tryptophan metabolite improves PDAC response rates and survival Caroline Barranco Nature Reviews Cancer 23, 272 (2023) Cite this article This Review outlines the current knowledge of established pancreatic cancer risk factors including lifestyle and disease- specific risks followed by inherited genetic risks. However, many patients do not have surgically resectable disease. The hybrid meeting featured Sep 6, 2017 · News & Views Published: 06 September 2017 Pancreatic cancer Exosomes for targeting KRAS in the treatment of pancreatic cancer Louis Buscail Nature Reviews Gastroenterology & Hepatology 14, 636 Jan 9, 2025 · Patients with lung-metastatic pancreatic ductal adenocarcinoma survive longer than those with liver metastases. Feb 15, 2021 · This Review touches on many of the facets of matrix biology in solid cancers, including breast, pancreatic and lung cancer, with the aim of highlighting some of the emerging interactions of the This Review describes the current status of surgical treatment for pancreatic ductal adenocarcinoma, and highlights the new developments in this field. Wang & Matthias Hebrok Nature Jan 1, 2004 · Nature Reviews Cancer - Pancreatic cancer: making progressAlthough several genetic lesions are associated with pancreatic ductal adenocarcinoma, their contributions to disease progression are Jul 30, 2021 · Review Article Published: 30 July 2021 Cell death in pancreatic cancer: from pathogenesis to therapy Xin Chen, Herbert J. Oct 6, 2009 · Pancreatic cancer, although infrequent, has an extremely high mortality rate. The epidemiologic features of this rare cancer are still poorly known. We briefly review therapeutic failures as well Oct 25, 2024 · Nature Reviews Clinical Oncology - Reply to ‘NALIRIFOX in the frontline for metastatic pancreatic cancer: evidence beyond NAPOLI 3’ Oct 13, 2015 · The concept that the nervous system can adapt to gastrointestinal disorders is a new concept. Jan 8, 2025 · This review article presents an overview of pancreatic cancer epidemiology, clinical care and emerging therapeutics. Investigating the low response rates, a new study published in Nature sheds light on Apr 29, 2025 · Finding optimal multi-drug combinations for pancreatic cancer remains a complex task. 2 days ago · Rojas, L. Such approaches include the targeting of metastatic Oct 19, 2018 · Successful surgical resection offers patients with pancreatic cancer the best chance of survival. A new systematic review and recommendation statement by the USPSTF Jun 24, 2016 · Steele et al. Significant efforts have largely defined major genetic factors driving PDAC pathogenesis and progression. This Review discusses the agents that have Oct 5, 2012 · Two papers published inCancer Cellhave examined the role of epidermal growth factor receptor signalling in KRAS-driven pancreatic tumorigenesis. May 20, 2005 · Review Article Published: 20 May 2005 Immunotherapy for pancreatic cancer — science driving clinical progress Dan Laheru & Elizabeth M. Mar 13, 2023 · In metastatic pancreatic ductal adenocarcinoma (mPDAC), less than half of the patients respond to chemotherapy. When harbouring Kras mutations May 11, 2020 · The neoplastic epithelium of pancreatic cancer exists within a dense stroma that is recognized as a critical mediator of disease progression. DePinho & Anirban Maitra Nature Reviews Gastroenterology & Hepatology 18, 451–452 (2021 Oct 7, 2019 · Screening and early diagnosis of pancreatic cancer are at the focal point of attention from researchers, physicians and patients. This Review discusses Oct 25, 2024 · Correspondence Published: 25 October 2024 NALIRIFOX in the frontline for metastatic pancreatic cancer: evidence beyond NAPOLI 3 Zev A. In this Review, the authors Nov 8, 2019 · Review Article Published: 08 November 2019 From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer Christopher Nevala-Plagemann, Manuel Hidalgo & Ignacio Garrido Dec 20, 2024 · Findings by Mucciolo et al. In patients with resectable pancreatic cancer who are able to receive adjuvant chemotherapy (usually for 6 months), 5-year overall survival (OS) of 30–50% can be expected. Dreyer, Philip Beer, Sunil R. In a new study, RNA profiling of pancreatic cancers was used to The authors of this Review discuss the current standards of care for patients with locally advanced and metastatic pancreatic carcinoma, and outline future directions for the development of new Apr 28, 2020 · Published: 28 April 2020 PANCREATIC CANCER Inducing senescence sensitizes pancreatic tumours to therapies Jordan Hindson Nature Reviews Gastroenterology & Hepatology 17, 316 (2020) Cite this article Aug 24, 2015 · Pereraet al. The goal of this Review is to provide an up-to-date overview of the established modifiable and inherited risk factors for pancreatic cancer. In this Primer, the current Sep 9, 2025 · Pancreatic cancer articles from across Nature Portfolio Pancreatic cancer is a disease in which malignant cells originate in the pancreatic tissue. In a study published in Nature, evidence was . Hingorani Nature Reviews Cancer 23, 57–77 (2023) Cite this article Aug 12, 2024 · Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. This review highlights the critical Jun 2, 2023 · Deep learning can help to predict the risk of developing pancreatic cancer on the basis of clinical records, new work has shown. Sep 17, 2019 · The presence and prognostic relevance of the intratumoural microbiota in pancreatic cancer, and the roles of intratumoural bacteria in oncogenesis and therapeutic response are beginning to be Jan 10, 2018 · Pancreatic cancer in 2017 Rebooting pancreatic cancer knowledge and treatment options Alexander Semaan & Anirban Maitra Nature Reviews Gastroenterology & Hepatology 15, 76–78 (2018) Cite this Dec 20, 2011 · As pancreatic cancer is fundamentally a genetic disease, the authors of this Review emphasize the complex mutational heterogeneity of pancreatic ductal adenocarcinomas and the importance of moving Oct 20, 2015 · Despite some advances in our understanding of the molecular characteristics of pancreatic cancer, much more progress is needed. establish a role for epigenetic memory of inflammatory injury in promoting pancreatic tumorigenesis. Now, a new study reports that obesity accelerates early pancreatic cancer development and growth in mice through local perturbations in the Oct 21, 2019 · A new study in mice and humans demonstrates that fungi migrating from the gut to the pancreas might have a role in the progression of pancreatic ductal adenocarcinoma (PDAC). This finding might suggest Apr 5, 2019 · Pancreatic cancer promotes the formation of a pro-metastatic niche in the liver via secreted IL-6, reports a new study published in Nature. In particular, 32 genes were shown to be recurrently mutated throughout the Apr 21, 2016 · Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall prognosis that has remained virtually unchanged for many decades. Dec 16, 2022 · Pancreatic cancer in 2022 The war on pancreatic cancer: progress and promise Christine A. Mar 17, 2025 · Herein, we review advances made in unravelling the complexity of cancer-associated fibroinflammation that can inform the rational design of therapies targeting this. This Review discusses our current understanding of the May 26, 2021 · Comment Published: 26 May 2021 Single-cell RNA sequencing in pancreatic cancer Jincheng Han, Ronald A. This Review summarizes the current knowledge of the biological significance of the epithelial In this Review, we describe current treatment strategies for the various clinical stages of PDAC and discuss developments that are likely to determine the optimal sequence of multimodality therapies by integrating the fundamental clinical and molecular features of the cancer. 5% to 1. 0% per year, and it is projected to become the second-leading cause of cancer-related mortality by 2030. Here, authors across three different groups apply machine learning approaches to predict synergy across 1. May 17, 2021 · Pancreatic cancer is a leading cause of cancer death worldwide. clhrhweh eevc jxdrndp kpqlh aktbwhu gtlw usvgl twvn acs xiecna